Osteogenic activity and antibacterial ability on titanium surfaces modified with magnesium-doped titanium dioxide coating.

doi:10.2217/nnm-2018-0413

Paper

Osteogenic activity and antibacterial ability on titanium surfaces modified with magnesium-doped titanium dioxide coating.

Published May 1, 2019 · Quan Zhao, Lei Yi, Libo Jiang

Nanomedicine

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32

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Abstract

Aim: To improve the bioactivity and antibacterial activity of titanium (Ti) implants. Materials & methods: Magnesium (Mg)-doped titanium dioxide microporous coatings (Mg-TiO2) were prepared on the surface of Ti implants by plasma electrolytic oxidation. Results: Ti surfaces were covered with porous Mg-TiO2, and Mg was evenly distributed throughout the coating. Mg-TiO2 could not only promote osteoblast adhesion, proliferation and differentiation but also inhibit the colonization and growth of Staphylococcus. In addition, Mg-TiO2 may promote osteogenesis through the ERK/c-Fos signaling pathway as well as the early osseointegration of Ti implants. Conclusion: Mg-TiO2 has both osteogenic and antibacterial effects and thus presents important theoretical significance and clinical potential.

In Vitro Study

Study Snapshot

Magnesium-doped titanium dioxide coatings on titanium implants improve bioactivity and antibacterial ability, promoting osteogenesis and early osseointegration.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Osteogenic activity and antibacterial ability on titanium surfaces modified with magnesium-doped titanium dioxide coating.

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References

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