N. Makarova, E. Boreko, I. K. Moiseev
Aug 1, 2003
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Journal
Pharmaceutical Chemistry Journal
Abstract
The high biological activity known for many compounds from the adamantane series [1 – 3], primarily for amines (among which the best known are midantan and remantadin), has stimulated experiments on directed modification of the amino group in adamantyl-containing amines and characterization of the biological activity of new compounds. Previously [4], we have reported on the psychotropic properties of some aminoketones of the adamantane series. The aim of this study was to characterize adamantyl-containing aminoketones (I, II) and their derivatives (III – VI, X, XII) with respect to antiviral activity. The synthesis and physicochemical characteristics of a part of these adamantyl-containing compounds were described previously: 2-(1-adamantyl)-1-(1-adamantylamino)ethan-2-one (I) [5], 1-(1-adamantylamino)-1-buten-3-one (II) [6]; 3-(1-adamantyl)-1-(methylamino)propan-3-ol (III) [7], and 3-(1-adamantyl)-1-(phenylaminonitroso)propan-3one (IV) [8].