Antibacterial activity and polarographic half-wave reduction potential of 2-nitrobenzo[b]furans.

doi:10.1248/CPB.33.2854

Paper

Antibacterial activity and polarographic half-wave reduction potential of 2-nitrobenzo[b]furans.

Published Jul 25, 1985 · Y. Ohishi, K. Kuriyama, Y. Doi

Chemical & pharmaceutical bulletin

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5

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0

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Abstract

The antibacterial activities of a series of 2-nitrobenzo [b] furan derivatives against St. aureus, B. subtilis, E. coli, Sal. typhimurium, Sal. enteritidis, Sh. flexneri, Pr. vulgaris or Ps. aeruginosa were determined in vitro. Most of the compounds showed considerable activities against the bacteria except Pr. vulgaris and Ps. aeruginosa and one of them was about 30 times as active as nitrofurantoin against St. aureus. Mono- and dimethoxy derivatives (2a, 3a, 4a, 5f) were the most active. The polarographic half-wave potentials (E1/2) of the 2-nitrobenzo [b] furans at pH 7 were in a narrow range of -0.450±0.04 V, whereas the E1/2 values of regioisomeric nitrobenzo [b] furans were more negative (-0.560--0.726 V). In the case of 2-nitrobenzo [b] furans, substituent (s) on the benzene ring had little influence on the reduction potential of the 2-nitro group, whereas the antibacterial activity depended markedly on the substituent group (s).

In Vitro Study

Study Snapshot

2-nitrobenzo[b]furans show considerable antibacterial activity against most bacteria, with their antibacterial activity largely dependent on the substituent group (s).

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Antibacterial activity and polarographic half-wave reduction potential of 2-nitrobenzo[b]furans.

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References

The Synthesis of Nitro, Amino, and Acetamino Derivatives of 2,3-Dimethylbenzofuran

This study demonstrates a new route for synthesis of nitro, amino, and acetamino derivatives of 2,3-dimethylbenzofuran, yielding new compounds such as aryloxybutanones, 2,3-dimethyl-4- and -7-nitrobenzofurans

Citations

Methods for the Preparation of 3-Nitrobenzofurans

3-nitrobenzofurans can be synthesized using electrophilic nitration of 3-unsubstituted benzofurans and the Nenitzescu indole synthesis from quinones and -nitroenamines.

Syntheses of 3-acetoacetylaminobenzo[b]furan derivatives having cysteinyl leukotriene 2 receptor antagonistic activity.

3-acetoacetylaminobenzo[b]furan derivatives with a modified triene system at the 3-position show moderate cysteinyl leukotriene 2 receptor antagonistic activity.

Electrochemical behaviour of pharmacologically interesting seleno-organic compounds—I. N-alkyl- and N-aryl-1,2-benzisoselenazol-3(2H)-one

The electrochemical behavior of seleno-organic compounds suggests a possible correlation between oxidation potential values and physiological activities.