S. Shanor, W. Kinnard, J. Buckley
Jun 1, 1965
Citations
0
Influential Citations
5
Citations
Quality indicators
Journal
Journal of pharmaceutical sciences
Abstract
The cardiovascular activities of mecamylamine, pempidine, and several pempidine analogs were investigated. The active compounds produced a significant drop in blood pressure and cardiac output in anesthetized normotensive dogs, markedly inhibited superior cervical ganglionic transmission in the cat, and produced a slight transient decrease in vascular resistance when administered intraarterially into the denervated perfused hind limb of the dog. Pempidine and N -amino- N -[ β -(2,2,6,6-tetramethylpiperidino)ethyl]guanidine sulfate (EX 4510) exhibited quantitatively and qualitatively similar hypotensive responses when administered orally to unanesthetized renal hypertensive dogs. The hypotensive activities of hexamethonium, pentolinium, chlorisondamine, mecamylamine, and pempidine were evaluated in the prostigminized rat. Prostigmine antagonized the hypotensive response of only hexamethonium, suggesting that hexamethonium alone produces a competitive type of antagonism at the autonomic ganglia.