Antibacterial activity and mechanism of action of chlorogenic acid.

doi:10.1111/j.1750-3841.2011.02213.x

Paper

Antibacterial activity and mechanism of action of chlorogenic acid.

Published Aug 1, 2011 · Z. Lou, Hongxin Wang, Song Zhu

Journal of food science

Q1 SJR score

543

Citations

13

Influential Citations

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Abstract

In this study, the antibacterial activity and mechanism of action of chlorogenic acid against bacteria were assessed. The data from minimum inhibitory concentration (MIC) values showed that chlorogenic acid effectively inhibited the growth of all tested bacterial pathogens, and the MIC values were ranging from 20 to 80 μg/mL. An investigation into action mode of chlorogenic acid against the pathogen indicated that chlorogenic acid significantly increased the outer and plasma membrane permeability, resulting in the loss of the barrier function, even inducing slight leakage of nucleotide. The leakage of cytoplasmic contents was also observed by electron micrographs. These results supported our hypothesis that chlorogenic acid bound to the outer membrane, disrupted the membrane, exhausted the intracellular potential, and released cytoplasm macromolecules, which led to cell death.

In Vitro Study

Highly Cited

Study Snapshot

Chlorogenic acid effectively inhibits bacterial growth by increasing membrane permeability, leading to cell death by disrupting the membrane and releasing cytoplasmic macromolecules.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Antibacterial activity and mechanism of action of chlorogenic acid.

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References

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Citations

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