Antimicrobial activity of N-chloramine compounds.

doi:10.1002/JPS.2600691116

Paper

Antimicrobial activity of N-chloramine compounds.

Published Nov 1, 1980 · H. H. Kohl, W. B. Wheatley, S. D. Worley

Journal of pharmaceutical sciences

Q2 SJR score

25

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0

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Abstract

Cellular mechanisms of action of two representative N-chloramines were studied. Both compounds, 3-chloro-4,4-dimethyl-2-oxazolidinone (I) and N-chlorosuccinimide (III), inhibited bacterial growth and exerted profound inhibition of bacterial DNA, RNA, and protein synthesis at a concentration of 10(-5) M. Enzymes containing sulfhydryl groups generally were significantly inhibited by these chloramines at 10(-4) M. Dihydrofolate reductase, which contains no sulfhydryl groups, also was inhibited but at much higher chloramine concentrations (10(-2) M); ribonuclease, which also contains no sulfhydryl groups, was unaffected. All of these inhibitory effects of the chloramines could be prevented if sulfhydryl-containing reagents (mercaptoethanol or dithiothreitol) were added before or together with the chloramine. Once inhibition was produced by the chloramine, it was not reversible by later addition of the sulfhydryl reagents. These results suggest that these chloramines act at sulfhydryl sites as well as at other sites in both cells and purified enzymes.

In Vitro Study

Study Snapshot

N-chloramine compounds inhibit bacterial growth and DNA, RNA, and protein synthesis, acting at sulfhydryl sites and other sites in cells and purified enzymes.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Antimicrobial activity of N-chloramine compounds.

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References

Inhibitory studies of DNA, RNA and protein synthesis in Escherichia coli by platinum containing complexes.

New platinum compounds show potential as 3-fold more potent inhibitors of Escherichia coli DNA, RNA, and protein synthesis than previously studied compounds.

Enhanced inhibition of both cellular protein synthesis and malate dehydrogenase by aged aquoplatinum(II) complexes.

Aged aquoplatinum(II) complexes significantly enhance their inhibitory properties against cellular protein synthesis and malate dehydrogenase, making them more effective anti-tumor agents.

Mass spectra of a series of 3‐halo‐2‐oxazolidinones

Fragmentation of 2-oxazolidinone ring systems is significantly influenced by the presence of alkyl substituents, their position, number, and size, and the substitution of NH by NCI and NBr.

Interactions of platinum complexes with the essential and nonessential sulfhydryl groups of thymidylate synthetate.

The trans isomer of Pt(NH3)2Cl2 preferentially inhibits thymidylate synthetase, while the cis isomer does not, suggesting that the enzyme's essential sulfhydryl groups are targeted by the two isomers.

N-Halo derivatives V: Comparative antimicrobial activity of soft N-chloramine systems.

Soft N-chloramines show promising antimicrobial activity, with factors such as chain length, chlorination degree, pH, denaturant presence, and positive charge influencing their effectiveness.

N-Halo derivatives VI: Microbiological and chemical evaluations of 3-chloro-2-oxazolidinones.

3-chloro-2-oxazolidinone III is the most useful bactericidal agent, with superior activity in presence of horse serum and greater stability compared to I and II.

N-halo derivatives III: stabilization of nitrogen-chlorine bond in N-chloroamino acid derivatives.

This study developed a series of low chlorine potential, soft antimicrobial N-chloramines based on alpha-aminoisobutyric acid derivatives, demonstrating improved stability and reactivity of nitrogen-chlorine bonds.

Photoelectron spectra, hydrolytic stability, and antimicrobial activity of N-chlorinated piperidines.

The stability of nitrogen lone pairs in N-chlorinated piperidines correlates with their antibacterial activity, as determined by photoelectron spectroscopy.

Dihydrofolate reductase from amethopterin-resistant Lactobacillus casei.

The dihydrofolate reductase from Lactobacillus casei is homologous with those from other bacteria, showing 29% sequence identity with Escherichia coli and 34% identity with Streptococcus faecium.

Citations

Broad-purpose antimicrobial chlorine-active polymers: suppression of multidrug-resistant microorganisms and microbial penetration resistance

Chlorine-active polymers show pronounced antimicrobial activity against multidrug-resistant microorganisms and high resistance to microbial penetration, making them promising for a wide range of medical products.

N-chlorosuccinimide enhancing the antimicrobial effect of benzalkonium chloride on biofilm Pseudomonas aeruginosa and its interaction mechanisms

N-chlorosuccinimide pretreatment significantly enhances the antimicrobial efficacy of benzalkonium chloride against biofilm Pseudomonas aeruginosa by 30% - 70%, reducing bacterial resistance.

Farmers or Nomads: Isotopic Evidence of Human–Animal Interactions (770BCE to 221BCE) in Northern Shaanxi, China

Human and pig populations in the Eastern Zhou Dynasty ate mainly C4-based foods, while cattle, horses, and sheep primarily relied on C3 plants, with pigs being the main source of animal protein.

Antibacterial N-halamine fibrous materials

N-halamine fibrous materials offer structural continuity, rapid sterilization, rechargeable bactericidal activity, and safety for humans and the environment, with potential applications in healthcare and environmental sectors.

Chemical Insights into Antibacterial N-Halamines.

N-halamines show promise as effective, long-lasting antibacterial agents due to their broad spectrum of microorganisms, stability, durability, and regeneration of their antibacterial properties.