Varsha J. Thombare, J. Holden, Sreetama Pal
Dec 1, 2017
Citations
0
Influential Citations
4
Citations
Journal
Tetrahedron
Abstract
Abstract Linear and bicyclic analogues of the peptide natural product, celogentin C, have been prepared in which the sidechain–sidechain crosslinks in celogentin are omitted or replaced with a mesitylenyl moiety. The simplified bicyclic peptides display moderate antibacterial activity, potentially through inhibition of bacterial protomicrotubule formation, while the linear analogs show higher antibacterial activity through a possible membrane disruption mechanism.