Huilin Li, Jing Zhang, Xuegong She
Sep 21, 2020
Citations
0
Influential Citations
5
Citations
Journal
Chemistry
Abstract
Diquinane or bicyclo[3.3.0]octane is a conspicuous structure unit existing in the carbo-frameworks of a wide range of natural products such as alkaloids and terpenoids. These diquinane-containing molecules not merely exhibit intriguing architectures, yet also showcase a broad spectrum of significant bioactivities, which draw widespread attention from the global synthetic community. During the past decade, with an aim to accomplish the total syntheses of such specified cornucopias of natural products, a variety of elegant strategies for construction of the diquinane ring system have been disclosed. In this review, we wish to demonstrate the most recent achievements on this subject in the timeline from 2010 to June 2020, and discuss how the diquinane unit is strategically forged in the context of the specific target structure. In addition, impacts of the selected works to the field of natural product total synthesis is highlighted and the particular outlook of diquinane-containing natural product synthesis is provided.