Paper
Recent advances in understanding the mechanism of action of bisphosphonates.
Published Jun 1, 2006 · F. Coxon, K. Thompson, M. Rogers
Current opinion in pharmacology
Q1 SJR score
257
Citations
7
Influential Citations
Abstract
Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.
Study Snapshot
Bisphosphonates effectively treat osteoporosis by inhibiting osteoclast-mediated bone resorption, and their mechanism of action may lead to the development of novel inhibitors of bone resorption.
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
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References
Selective inhibition of Rab prenylation by a phosphonocarboxylate analogue of risedronate induces apoptosis, but not S‐phase arrest, in human myeloma cells
Selective inhibition of Rab prenylation by a phosphonocarboxylate analogue of risedronate induces apoptosis in human myeloma cells, but not S-phase arrest, identifying distinct molecular pathways responsible for antimyeloma effects.
2006·61citations·A. Roelofs et al.·International Journal of Cancer
International Journal of Cancer
Relative binding affinities of bisphosphonates for human bone and relationship to antiresorptive efficacy.
Most clinically tested bisphosphonates have similar affinities for human bone, but those with reduced affinity may have lower antiresorptive potency, necessitating higher dosing.
2006·147citations·C. Leu et al.·Bone
Bone
Inhibition of Protein Prenylation by Bisphosphonates Causes Sustained Activation of Rac, Cdc42, and Rho GTPases
N-BPs inhibit bone resorption by preventing prenylation of small GTPases, leading to the accumulation of unprenylated small GTPases and inappropriate activation of downstream signaling pathways.
2006·178citations·J. Dunford et al.·Journal of Bone and Mineral Research
Journal of Bone and Mineral Research
Cytosolic Entry of Bisphosphonate Drugs Requires Acidification of Vesicles after Fluid-Phase Endocytosis
Bisphosphonate drugs enter cells through fluid-phase endocytosis, which is enhanced by calcium ions, and then enter the cytosol through endosomal acidification.
2006·241citations·K. Thompson et al.·Molecular Pharmacology
Molecular Pharmacology
Citations
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2024·0citations·Bence Bojtor et al.·International Journal of Molecular Sciences
International Journal of Molecular Sciences
Lysosomal biogenesis and function in osteoclasts: a comprehensive review
Targeting lysosomes in osteoclasts may offer potential therapeutic benefits for treating bone metabolic disorders.
2024·0citations·Junchen Jiang et al.·Frontiers in Cell and Developmental Biology
Frontiers in Cell and Developmental Biology
Hydroxychloroquine and a low activity bisphosphonate conjugate prevent and reverse ovariectomy-induced bone loss in mice through dual antiresorptive and anabolic effects
The combination of HABP and HCQ could prevent and treat osteoporosis by promoting bone formation and decreasing bone resorption simultaneously.
2024·0citations·Z. Yao et al.·Research Square
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Discovery of a Potent Antiosteoporotic Drug Molecular Scaffold Derived from Angelica sinensis and Its Bioinspired Total Synthesis
Falcarinphthalide A (1), a promising lead compound from Angelica sinensis, exhibits potent antiosteoporotic activity by inhibiting NF-B and c-Fos signaling-mediated osteoclastogenesis.
2024·5citations·Jian Zou et al.·ACS Central Science
ACS Central Science
Enhancing Osteosarcoma Therapy through Aluminium Hydroxide Nanosheets-Enabled Macrophage Modulation.
Aluminium hydroxide nanosheets combined with zoledronic acid can enhance osteosarcoma therapy by inhibiting cell growth and enhancing macrophage activation.
2023·1citation·Min Cheng et al.·International journal of pharmaceutics
International journal of pharmaceutics