Antidepressant agents. 9. 3,3-Diphenylcyclobutylamines, a new class of central stimulants.

doi:10.1021/JM00199A014

Paper

Antidepressant agents. 9. 3,3-Diphenylcyclobutylamines, a new class of central stimulants.

Published 1978 · B. Carnmalm, S. Rämsby, A. L. Renyi

Journal of medicinal chemistry

Q1 SJR score

6

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0

Influential Citations

Full textSemantic Scholar

Abstract

3,3-Diphenylcyclobutylamine (4), N-methyl-3,3-diphenylcyclobutylamine (6), and N,N-dimethyl-3,3-diphenyl-cyclobutylamine (7) have been prepared and tested as potential antidepressant agents. The secondary (6) and tertiary (7) amines strongly decrease the accumulation of NA and 5-HT in brain slices in vitro and in vivo. The cyclobutylamines also cause motor stimulation. The most potent compound in this respect is the tertiary amine 7. The increase in locomotion is not blocked by pretreatment with phenoxybenzamine, methergoline, or alpha-methyltyrosine. Pretreatment with pimozide or reserpine reduces the hyperactivity induced by 7. This hyperstimulation seems to be caused by a mechanism of action which differs from that of amphetamine. 7 may cause increase in locomotion by release of dopamine from granular stores.

Study Snapshot

3,3-Diphenylcyclobutylamines show potential as antidepressant agents by decreasing NA and 5-HT accumulation in brain, while also causing motor stimulation.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Antidepressant agents. 9. 3,3-Diphenylcyclobutylamines, a new class of central stimulants.

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References

Citations

Stereoselective reduction of N-(3-arylcyclobutylidene)amines

N-alkyl-N-(3-arylcyclobutylidene)amines can be reduced to cis-substituted cyclobutylamines with borane, yielding a stable intermediate imine-borane complex.

The central stimulatory action of inhibitors of the dopamine uptake.

(+)-amphetamine causes hyperactivity by releasing dopamine, while the other compounds inhibit dopamine re-uptake, with reserpine enhancing (+)-amphetamine's potency.

Chapter 1 Antidepressants

Antidepressants work by inhibiting noradrenergic and 5-HT uptake in the brain, with their effectiveness influenced by their metabolites and their effects on 5-HT receptor supersensitivity.