Antiallergic agents. 3. N-(1H-tetrazol-5-yl)-2-pyridinecarboxamides.

doi:10.1021/JM00368A005

Paper

Antiallergic agents. 3. N-(1H-tetrazol-5-yl)-2-pyridinecarboxamides.

Published Feb 1, 1984 · Y. Honma, K. Hanamoto, T. Hashiyama

Journal of medicinal chemistry

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Abstract

A series of N-tetrazolylpyridinecarboxamides was prepared and evaluated for antiallergic activity by the passive cutaneous anaphylaxis (PCA) assay. From the structure-activity relationships (SAR) of this class of compounds, it was revealed that the N-tetrazolylcarbamoyl group as an acidic functionality is required to be at the 2-position of the pyridine nucleus and that the phenyl group as a subtituent is not necessarily required for activity. 6-Methyl-N-(1H-tetrazol-5-yl)-2-pyridinecarboxamide (36) showed good oral activity and low toxicity.

Study Snapshot

N-tetrazolylpyridinecarboxamides show good oral activity and low toxicity, with the 6-Methyl-N-(1H-tetrazol-5-yl)-2-pyridinecarboxamide (36) showing good oral activity and low toxicity.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Antiallergic agents. 3. N-(1H-tetrazol-5-yl)-2-pyridinecarboxamides.

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References

Citations

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N-p-chlorobenzyl-(E)-4'-hydroxy-4-stilbazolium chlorides show yellow, red, and yellow-red colors in extra dry solvents, with varying intensities in water-containing solutions.

Synthesis and antihypertensive activity of N-acetylmercaptopropionyl-6-(2′-phenylethyl)pipecolinic acids

N-acetylmercaptopropionyl-6-(2′-phenylethyl)pipecolinic acids show antihypertensive activity by inhibiting the formation of angiotensin II and the breakdown of kinins, resulting in a decrease in arterial pressure.

Leukotrienes and antileukotrienic preparations: Trends in the search and medical applications (review)

Leukotrienes are a new class of biologically active substances, the biotransformation products of arachidonic acid, with potential medical applications in allergic reactions and asthma.

Clinical pharmacological evaluation of a new anti-allergic agent, TA-5707, by skin and nasal provocation tests.

TA-5707 effectively inhibits skin and nasal allergic reactions, with no observed adverse reactions in patients with allergic rhinitis.

Studies on a new antiallergic pyridinecarboxamide TA-5707F and its sodium salt (TA-5707). I. Inhibition of IgE-induced passive cutaneous anaphylaxis (PCA) in rats.

TA-5707F and TA-5707 effectively inhibit IgE-induced passive cutaneous anaphylaxis in rats, with no drug tolerance observed after 8 days of daily administration.

Chapter 10. Pulmonary and Antiallergy Agents

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