Feb 7, 2020
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Abstract
T he hydrochloride salt form of alosetron, a potent and selective 5-HT 3 receptor antagonist. Alosetron blocks the actions of serotonin at 5-HT 3 sites in the peripheral nervous system, particularly on enteric and nociceptive sensory neurons, thereby affecting the regulation of visceral pain, decreasing gastrointestinal contraction and motility, and decreasing gastrointestinal secretions. T his agent is used to treat diarrheapredominant irritable bowel syndrome in women. Qeios · Definition, February 7, 2020