M. Landwehr, L. Hochrein, Christopher R. Otey
May 10, 2006
Citations
1
Influential Citations
133
Citations
Quality indicators
Journal
Journal of the American Chemical Society
Abstract
Here we report that an engineered microbial cytochrome P450 BM-3 (CYP102A subfamily) efficiently catalyzes the alpha-hydroxylation of phenylacetic acid esters. This P450 BM-3 variant also produces the authentic human metabolite of buspirone, R-6-hydroxybuspirone, with 99.5% ee.