Mathieu Bibian, Jean Martínez, J. Fehrentz
Sep 16, 2011
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Influential Citations
12
Citations
Journal
Tetrahedron
Abstract
We report on the synthesis of 1,2,4-triazoles substituted with 2 or 3 amino acid side chains, using silver benzoate as a key reagent for the cyclization step. A complete study of the optical purity retention during the synthetic process leading to these compounds is described. In addition an improved work-up after the addition-cyclization step was also established leading to better yields and metal-free products.