Zhenxing Xi, Hassan S. Bazzi, J. Gladysz
Nov 9, 2011
Citations
0
Influential Citations
18
Citations
Journal
Organic letters
Abstract
Analogs of Grubbs' second generation catalyst with hydrophilic phosphine ligands are synthesized, and those with Cy(2)PCH(2)CH(2)N(CH(3))(3)(+) Cl(-) and Cy(2)PCHCH(2)CH(2)N(CH(3))(2)(+)CH(2)CH(2) Cl(-) give much faster ring closing metatheses under CH(2)Cl(2)/aqueous or CH(2)Cl(2)/aqueous HCl biphasic as opposed to CH(2)Cl(2) monophasic conditions. This is attributed to rapid phase transfer of the dissociated ligand to the aqueous phase, where under acidic conditions it is protonated.