E. Laurini, Valentina Da Col, B. Wünsch
May 15, 2013
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0
Influential Citations
24
Citations
Journal
Bioorganic & medicinal chemistry letters
Abstract
The highly selective σ1 receptor antagonist S1RA is endowed with a surprisingly high affinity for its target protein given a missing fundamental hydrophobic pharmacophoric requirement. Here we show that, with respect to other potent σ1 ligands, S1RA is able to compensate this loss by fulfilling all other pharmacophoric requirements and by gaining in solvation energy.