I. T. Shadi, B. Chowdhry, S. Leharne
Jun 1, 2004
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Abstract
Quinine, formerly used as an anti-malarial drug, is still widely used for interdisciplinary scientific investigations with potential applied applications e.g. for the synthesis of polyfunctional chiral solvating agents [1]. Tonic water, which contains quinine, is often used in undergraduate chemistry experiments to demonstrate the analytical sensitivity of fluorescence for the detection of quinine. Raman spectroscopy has been used to investigate the vibrational spectra of quinine sulfate in the powdered and solution state. In addition SERS spectra of quinine sulfate have also been obtained and are compared with the SERS spectra obtained for both neat and diluted samples of tonic water as a means of undertaking, semi-quantitatively, trace analysis of quinine in tonic water. The sensitivity of the SERS technique is compared with that of fluorescence spectroscopy. A citrate reduced silver sol was employed and prepared using the modified Lee-Meisel procedure [2, 3].