E. Barteneva, O. B. Stepanenko, N. I. Avdyunina
Dec 1, 2004
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Journal
Pharmaceutical Chemistry Journal
Abstract
As is known, the class of 2-mercaptobenzimidazole derivatives contains substances possessing adaptogen, cardiotropic, gastroprotective, and anxiolytic properties [1 – 4]. A new original domestic drug, bradizol, also belonging to this class, produces antiischemic and antiarrhythmic action [5]. Now bradizol is in the stage of clinical investigation as a specific antibradycardic drug. The chemical structure of bradizol corresponds to 2-[2-(diethylamino)ethylthio]-5-ethoxybenzimidazole dihydrochloride: