Paper
Carbonic anhydrase inhibitors: sulfonamides as antitumor agents?
Published Mar 1, 2001 · C. Supuran, F. Briganti, Silvia Tilli
Bioorganic & medicinal chemistry
Q2 SJR score
242
Citations
1
Influential Citations
Abstract
Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.
Highly CitedStudy Snapshot
Novel sulfonamide inhibitors of carbonic anhydrase show potent inhibition of tumor cell growth, potentially leading to the development of effective novel anticancer agents.
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
Sign up to use Study Snapshot
Consensus is limited without an account. Create an account or sign in to get more searches and use the Study Snapshot.
Full text analysis coming soon...
References
Novel sulphonamide derivatives for the treatment of cancer
Novel sulphonamide derivatives show promising anti-tumor activity, with potential mechanisms including microtubule assembly disruption, cell cycle arrest, and angiogenesis inhibition.
2000·133citations·T. Owa et al.·Expert Opinion on Therapeutic Patents
Expert Opinion on Therapeutic Patents
Carbonic anhydrase inhibitors - Part 94. 1,3,4-Thiadiazole-2-sulfonamide derivatives as antitumor agents?
1,3,4-thiadiazole-2-sulfonamide derivatives show potential as effective in vitro tumor cell growth inhibitors against various cancer cell lines.
2000·101citations·C. Supuran et al.·European Journal of Medicinal Chemistry
European Journal of Medicinal Chemistry
A focused compound library of novel N-(7-indolyl)benzenesulfonamides for the discovery of potent cell cycle inhibitors.
Novel N-(7-indolyl)benzenesulfonamide compounds show potential as potent cell cycle inhibitors, disrupting mitosis and causing G1 accumulation in P388 murine leukemia cells.
2000·51citations·T. Owa et al.·Bioorganic & medicinal chemistry letters
Bioorganic & medicinal chemistry letters
Carbonic anhydrase inhibitors: synthesis of N-morpholylthiocarbonylsulfenylamino aromatic/heterocyclic sulfonamides and their interaction with isozymes I, II and IV.
N-morpholylthiocarbonylsulfenyl derivatives show nanomolar inhibition against three carbonic anhydrase isozymes and show inhibitory properties against various cancer cell lines.
2000·22citations·A. Scozzafava et al.·Bioorganic & medicinal chemistry letters
Bioorganic & medicinal chemistry letters
Carbonic anhydrase inhibitors and their therapeutic potential
Carbonic anhydrase inhibitors show potential as diuretics, treatments for various diseases, and diagnostic tools, due to their widespread distribution in higher vertebrates and their role in physiological functions.
2000·480citations·C. Supuran et al.·Expert Opinion on Therapeutic Patents
Expert Opinion on Therapeutic Patents
Citations
Drug Delivery Systems of Betulin and Its Derivatives: An Overview
Recent advancements in drug delivery systems, primarily nanoparticles, show promise in overcoming barriers faced in clinical application of betulin and its derivatives.
2024·3citations·Bartosz Jaroszewski et al.·Biomedicines
Biomedicines
Novel Secondary Pyridinyl Amides: Synthesis, In Vitro Antiproliferative Screenings, and Molecular Docking Studies
Compound 3 shows the best antiproliferative activity against human leukemias and hepatocellular carcinomas, binding effectively to bcr/abl, EGFR, and HER2 tyrosine kinases.
2024·0citations·Chase Verdugo et al.·Journal of Molecular Structure
Journal of Molecular Structure
A multi-institutional phase I study of acetazolamide with temozolomide in adults with newly diagnosed MGMT-methylated malignant glioma
Acetazolamide is a safe and tolerable addition to standard temozolomide treatment for MGMT-methylated malignant glioma, potentially improving survival rates and potentially serving as a biomarker for prognosis.
2024·3citations·Riley K Driscoll et al.·Neuro-Oncology Advances
Neuro-Oncology Advances
Benzenesulfonamide based 1,3,4-oxadiazole derivatives: synthesis, pharmacokinetic property prediction, bovine carbonic anhydrase activity and molecular docking studies
The compound (5o) shows the best inhibitory effect against Bovine Carbonic Anhydrase, with no significant toxicity except hepatotoxicity.
2023·4citations·E. Alpınar et al.·Journal of Sulfur Chemistry
Journal of Sulfur Chemistry
A DNA-encoded chemical library based on chiral 4-amino-proline enables stereospecific isozyme-selective protein recognition
A DNA-encoded chemical library based on chiral 4-amino-proline enables stereospecific isozyme-selective protein recognition, potentially enabling targeted therapy for cancer.
2023·12citations·S. Oehler et al.·Nature Chemistry
Nature Chemistry
Five-Membered Heterocyclic Sulfonamides as Carbonic Anhydrase Inhibitors
Five-membered heterocyclic sulfonamides are more effective carbonic anhydrase inhibitors, with diverse biological activities, such as antiglaucoma, antiepileptic, antitumor, and antiinfective properties.
2023·15citations·A. Angeli et al.·Molecules
Molecules
Synthesis, Biological Evaluation, and Molecular Modeling Studies of New 1,3,4‐Thiadiazole Derivatives as Potent Antimicrobial Agents
New 1,3,4-thiadiazole derivatives show promising antimicrobial activity against bacteria and fungal strains, with compounds 3f and 3g showing promising antifungal activity.
2023·14citations·U. Acar Çevik et al.·Chemistry & Biodiversity
Chemistry & Biodiversity