Xiaoqing Xin, Peng-mian Huang, Dexuan Xiang
Jan 17, 2013
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0
Influential Citations
11
Citations
Journal
Organic & biomolecular chemistry
Abstract
A facile and efficient synthetic route to multi-substituted 2-aminopyridines has been developed via a formal [5C + 1N] annulation of readily available 2,4-pentadienenitriles with hydroxylamine (NH(2)OH) under very mild conditions, which involves sequential intermolecular aza-nucleophilic addition of hydroxylamine, intramolecular aza-cyclization, and dehydration reactions.