V. B. Tatipamula, G. Vedula
Jul 6, 2019
Citations
1
Influential Citations
10
Citations
Journal
Journal of The Serbian Chemical Society
Abstract
The chemical investigation of lichen Ramalina leiodea (Nyl.) Nyl. yielded five known metabolites, i.e ., usnic acid ( 1 ), ethyl everninate ( 2 ), scrobiculin ( 3 ), methyl 2,6-dihydroxy-4-methylbenzoate ( 4 ) and 4-[(2-hydroxy-4-methoxy-6-propylbenzoyl)oxy]-2-methoxy-6-propylbenzoic acid ( 5 ). To develop compound libraries on 4 , a series of semi-synthetic derivatives was prepared ( 4a – e ). All the metabolites and semi-synthetic analogues were screened for antimicrobial and anti-tubercular activities. The results showed that compounds 3 and 5 were very active against antibacterial and antifungal strains, while the semi-synthetic analogues 4a – e are moderately active on all tested microbial strains. In addition, compounds 4b and 4d showed better antimycobacterial activity with MIC value of 1.6 µg mL-1, than streptomycin with an MIC of 6.25 µg mL-1 against M. tuberculosis . All the semi-synthetic analogues exhibited better anti-tubercular activity than the isolated metabolites. This is the first report on the synthesis and biological activities of these novel benzohydrazide derivatives.