Anti-Aging and Neuroprotective Properties of Grifola frondosa and Hericium erinaceus Extracts

doi:10.3390/nu14204368

Paper

Anti-Aging and Neuroprotective Properties of Grifola frondosa and Hericium erinaceus Extracts

Published Oct 1, 2022 · F. Tripodi, E. Falletta, M. Leri

Nutrients

Q1 SJR score

22

Citations

0

Influential Citations

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Semantic Scholar

Abstract

Nutrition has relevant consequences for human health and increasing pieces of evidence indicate that medicinal mushrooms have several beneficial effects. One of the main issues in Western countries is represented by the challenges of aging and age-related diseases, such as neurodegenerative disorders. Among these, Parkinson’s disease (PD) affects 10 million people worldwide and is associated with α-synuclein misfolding, also found in other pathologies collectively called synucleinopathies. Here, we show that aqueous extracts of two edible mushrooms, Grifola frondosa and Hericium erinaceus, represent a valuable source of β-glucans and exert anti-aging effects in yeast. Their beneficial effects are mediated through the inhibition of the Ras/PKA pathway, with increased expression of heat shock proteins, along with a consistent increase of both mean and maximal lifespans. These fungal extracts also reduce the toxicity of α-synuclein heterologously expressed in yeast cells, resulting in reduced ROS levels, lower α-synuclein membrane localization, and protein aggregation. The neuroprotective activity of G. frondosa extract was also confirmed in a PD model of Drosophila melanogaster. Taken together, our data suggest the use of G. frondosa and H. erinaceus as functional food to prevent aging and age-related disorders, further supporting the neuro-healthy properties of these medicinal mushroom extracts.

In Vitro Study

Very Rigorous Journal

Study Snapshot

Key takeawayGrifola frondosa and Hericium erinaceus mushroom extracts show anti-aging effects and neuroprotective properties, suggesting their potential as functional foods to prevent aging and age-related disorders.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Anti-Aging and Neuroprotective Properties of Grifola frondosa and Hericium erinaceus Extracts

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References

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Hericium erinaceus primordium extract, rich in Ergothioneine, shows neuro-protective and preventive effects against locomotor decline during aging, likely due to its high ERGO content.

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Grifola frondosa (Maitake) extract reduces fat accumulation and improves health span in C. elegans through the DAF-16/FOXO and SKN-1/NRF2 signaling pathways.

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Erinacine A-enriched Hericium erinaceus mycelium (EAHEM) improves learning and memory and delays degenerative aging in mice brains, with the lowest dose of 108 mg/kg/BW being sufficient for these effects.

Citations

Some Applications of Hericium erinaceus Mushrooms: A Review

Hericium erinaceus mushrooms show potential as natural cures for various illnesses due to their anti-inflammatory, neuroprotective, anti-oxidant, and immune-modulatory effects.

Effect of Solid-State Fermentation of Hericium erinaceus on the Structure and Physicochemical Properties of Soluble Dietary Fiber from Corn Husk

Solid-state fermentation of Hericium erinaceus significantly improves the structure and physicochemical properties of soluble dietary fiber from corn husks, increasing their water-holding, swelling, and oil-holding capacities.

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This study developed a SNP molecular identification system in Grifola frondosa, providing an accurate, rapid, and efficient method for identifying germplasm resources and identifying mushroom varieties.

Biological Activities of Ethanol Extracts of Hericium erinaceus Obtained as a Result of Optimization Analysis

Ethanol extracts of Hericium erinaceus mushroom show high antioxidant potential, antimicrobial activity, and anti-Alzheimer activity when extracted under optimal conditions.

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Lion's Mane mushroom has potential as a natural remedy for cognitive health, mood disorders, and addressing chronic diseases like obesity, high blood pressure, hepatic disorders, and cancer.

Unlocking the Power: New Insights into the Anti-Aging Properties of Mushrooms

Mushrooms contain bioactive compounds that show promise in combating skin aging and age-related diseases, potentially extending lifespan and improving health span.

Isolation and identification of active components from Grifola frondosa and its anti-EV71 virus effect.

L-tryptophan, a component of Grifola frondosa, shows anti-EV71 virus activity, which could be used in infant nutrition and potentially provide a new drug to treat hand, foot, and mouth disease.

Artemisia argyi extract exerts antioxidant properties and extends the lifespan of Drosophila melanogaster.

Artemisia argyi extract effectively extends the lifespan of Drosophila melanogaster, improving its climbing ability and tolerance to hydrogen peroxide, with potential applications in nutraceutical industry.