Paper
[Antiarrhythmic properties of 3-(2-hydroxy-3 isopropylamino-propoxy)-3 phenyl-2 isoindolinone-1, (RS, SR) in the dog].
Published Feb 5, 1979 ยท J. Detaille, C. Caillard, S. Mondot
Comptes rendus des seances de l'Academie des sciences. Serie D, Sciences naturelles
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Abstract
In the Dog, 3-(2-hydroxy-3 isopropylamino-proxy)-2-phenyl-1-isoindolinone (RS, SR) possesses an anti-arrhythmic activity similar to that of quinidine but at dose levels 2 to 6 times lower than in the case of the latter compound. Furthermore, in contrast to quinidine, at the dose levels where the antiarrhythmic activity is well observed, the compound is devoid of hypotensive activity and of depressive action on cardiac contractility. The first clinical studies of this compound have shown its usefulness in the treatment of ventricular and supraventricular arrhythmias.
3-(2-hydroxy-3 isopropylamino-propoxy)-2-phenyl-1-isoindolinone (RS, SR) shows anti-arrhythmic activity similar to quinidine at lower doses, making it useful for treating ventricular and supraventricular arrhythmias without hypotension
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