M. Taha, S. M. El-Badry
2010
Citations
0
Influential Citations
6
Citations
Journal
Journal of The Korean Chemical Society
Abstract
ABSTRACT. Ethyl 1-aminotetrazole-5-carboxylate ( 1 ) reacted with hydrazine hydrate to give the corresponding aminohydrazide 2 . Cyclization of 2 by carbon disulfide yielded 1,3,4-oxadiazole-5-thiol structure 3 . Reaction of 3 with either chloroacetone or ethyl chloroacetate furnished S-acyl 1,3,4-oxadiazole derivatives 4 and 5 , respectively. Also compound 3 reacted with hydrazine hydrate afforded 4-amino-1,2,4-triazole-5-thiol derivative 6 . 6-Methyl-1,3,4-triazolo[3,4- b ]-1,3,4-thiadiazole structure 7 was synthesized by reaction of aminothiol 6 with glacial acetic acid. Diazotization of 1 with sodium nitrite in presence of hydrochloricacid yielding the diazonium salt which on treating with hippuric acid, oxazolone derivative 8 was obtained. Furthermore, tetra-zolo[5,1- f ]-1,2,4-triazine 9 was constructed via cyclization of aminoester 1 with formamide. Compound 9 reacted with carbon disulfide to furnish 8-thione derivative 10 which reacting with chloroacetone, ethyl chloroacetate, and hydrazine hydrate, the corresponding chemical structures