Ching-Yu Shih, I-Hshin Lin, James-Cheng Ding
Mar 1, 2014
Citations
0
Influential Citations
9
Citations
Quality indicators
Journal
British Journal of Pharmacology
Abstract
The transcription factor NF‐κB, stimulates platelet aggregation through a non‐genomic mechanism. Nifedipine, a voltage‐gated L‐type calcium channel blocker, is widely used to treat hypertension. Nifedipine also displays antiplatelet activity, but the underlying mechanisms involved remain unclear. This study was designed to investigate whether the antiplatelet effects of nifedipine are mediated by regulating NF‐κB‐dependent responses.