Antituberculosis activity of hydrazones derived from 4-fluorobenzoic acid hydrazide

doi:10.1007/s00044-008-9126-z

Paper

Antituberculosis activity of hydrazones derived from 4-fluorobenzoic acid hydrazide

Published May 1, 2009 · B. Koçyiğit-Kaymakçıoğlu, Emine Elçin Oruç-Emre, S. Unsalan

Medicinal Chemistry Research

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37

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Abstract

A series of substitututed methylene/ethylene 4-fluorophenylhydrazide derivatives (3a–p) was synthesized with the aim of evaluating their antimycobacterial activity toward a strain of Mycobacterium tuberculosis H37Rv. Their chemical structures were confirmed by ^1H-nuclear magnetic resonance (NMR) and electrospray mass spectrometry (ES-MS) spectral data, and elemental analysis. The in vitro antimycobacterial evaluation was performed according to the Tuberculosis Antimicrobial Acquisition and Coordinating Facility (TAACF) antituberculosis drug discovery program. Compound 3a, 4-fluorobenzoic acid [(2,6-dichlorophenyl) methylene]hydrazide, showed the highest inhibitory activity of all the compounds under study.

In Vitro Study

Study Snapshot

Compound 3a, 4-fluorobenzoic acid [(2,6-dichlorophenyl) methylene]hydrazide, showed the highest inhibitory activity against Mycobacterium tuberculosis H37Rv.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Antituberculosis activity of hydrazones derived from 4-fluorobenzoic acid hydrazide

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