Paper
Antitumor and chemosensitizing action of 3-bromopyruvate: Implication of deregulated metabolism.
Published May 25, 2017 · S. Yadav, Shrish Pandey, Ajay Kumar
Chemico-biological interactions
Q1 SJR score
34
Citations
2
Influential Citations
Abstract
Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.
In Vitro StudyStudy Snapshot
3-Bromopyruvate shows strong antitumor potential against thymic tumors by inhibiting metabolism and survival, promoting apoptosis and necrosis, and enhancing chemosensitivity.
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
Sign up to use Study Snapshot
Consensus is limited without an account. Create an account or sign in to get more searches and use the Study Snapshot.
Full text analysis coming soon...
References
Cancer metabolism: a therapeutic perspective
Targeting metabolic differences between tumor and normal cells holds promise as a novel anticancer strategy, as cancer cells reprogramme their metabolism to survive and propagate, driving disease progression.
2017·1214citations·U. Martinez-Outschoorn et al.·Nature Reviews Clinical Oncology
Nature Reviews Clinical Oncology
Hypermethylation of ATP‐binding cassette B1 (ABCB1) multidrug resistance 1 (MDR1) is associated with cisplatin resistance in the A549 lung adenocarcinoma cell line
Hypermethylation of the ABCB1 gene is associated with increased gene expression and cisplatin resistance in human lung adenocarcinoma cells.
2016·25citations·Angui Li et al.·International Journal of Experimental Pathology
International Journal of Experimental Pathology
Differential 3-bromopyruvate inhibition of cytosolic and mitochondrial human serine hydroxymethyltransferase isoforms, key enzymes in cancer metabolic reprogramming.
3-bromopyruvate selectively inactivates human SHMT1 and SHMT2, targeting Cys204, offering potential for developing selective inhibitors targeting this enzyme for cancer treatment.
2016·39citations·A. Paiardini et al.·Biochimica et biophysica acta
Biochimica et biophysica acta
Hepatotoxicity and nephrotoxicity of 3-bromopyruvate in mice.
3-Bromopyruvate at 8mg/kg effectively suppresses tumor growth without causing liver or kidney damage in nude mice, but shows liver damage at 16mg/kg in Kunming mice.
2016·11citations·Q. Pan et al.·Acta cirurgica brasileira
Acta cirurgica brasileira
AMP‐activated protein kinase couples 3‐bromopyruvate‐induced energy depletion to apoptosis via activation of FoxO3a and upregulation of proapoptotic Bcl‐2 proteins
AMPK plays a crucial role in coupling 3BP-induced metabolic disruption to intrinsic apoptosis in cancer cells by activating the FoxO3a-Bim axis and upregulating proapoptotic Bcl-2 proteins.
2016·20citations·C. Bodur et al.·Molecular Carcinogenesis
Molecular Carcinogenesis
Citations
3-Bromopyruvate modified with cholesterol enhances anti-hepatoma activity by inducing ferroptosis and apoptosis
3-BP-CL, a pH-responsive prodrug, shows potential in hepatoma treatment by inducing ferroptosis and apoptosis, with no toxicity observed in mice.
2024·0citations·Wen-jun Pei et al.·Journal of Drug Delivery Science and Technology
Journal of Drug Delivery Science and Technology
Targeting metabolic reprogramming in hepatocellular carcinoma to overcome therapeutic resistance: A comprehensive review.
Targeting metabolic enzymes with inhibitors can alleviate resistance and improve treatment effectiveness in hepatocellular carcinoma.
2023·8citations·Qi Wang et al.·Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Potential therapies targeting nuclear metabolic regulation in cancer
Nuclear metabolic signaling plays a crucial role in cancer biology, offering potential therapeutic targets and pharmacological interventions for targeting the metabolism-genome transcriptional axis.
2023·2citations·Yanjie Chen et al.·MedComm
MedComm
Succinate metabolism: a promising therapeutic target for inflammation, ischemia/reperfusion injury and cancer
Succinate metabolism and the regulation of SDH show potential as therapeutic targets for treating chronic inflammation, ischemia/reperfusion injury, and cancer in hypoxia-related diseases.
2023·12citations·Wenhui Zhang et al.·Frontiers in Cell and Developmental Biology
Frontiers in Cell and Developmental Biology
Metabolic Reprogramming and Potential Therapeutic Targets in Lymphoma
Metabolic reprogramming in lymphoma cells contributes to tumorigenesis, disease progression, and resistance to chemotherapy, and understanding these pathways may lead to potential therapeutic targets and biomarkers.
2023·7citations·Yuyang Pang et al.·International Journal of Molecular Sciences
International Journal of Molecular Sciences
Interfering biosynthesis by nanoscale metal-organic frameworks for enhanced radiation therapy.
Nanoscale metal-organic frameworks loaded with 3-bromopyruvate can overcome radiation therapy resistance and enhance cancer treatment efficacy by reducing DNA damage repair and enhancing X-ray deposition.
2023·13citations·Zi Fu et al.·Biomaterials
Biomaterials
3-Bromopyruvic acid regulates glucose metabolism by targeting the c-Myc/TXNIP axis and induces mitochondria-mediated apoptosis in TNBC cells
3-BrPA inhibits TNBC cell proliferation by targeting the c-Myc/TXNIP axis, inhibiting glycolysis, and inducing mitochondrial-mediated apoptosis.
2022·12citations·Jiachen Li et al.·Experimental and Therapeutic Medicine
Experimental and Therapeutic Medicine
Metabolic dysregulation and emerging therapeutical targets for hepatocellular carcinoma
Targeting abnormal metabolism in glucose, fatty acid, amino acid, and glutamine metabolism may offer new treatment options for hepatocellular carcinoma.
2021·281citations·Danyu Du et al.·Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica. B
Methyl Jasmonate Cytotoxicity and Chemosensitization of T Cell Lymphoma In Vitro Is Facilitated by HK 2, HIF-1α, and Hsp70: Implication of Altered Regulation of Cell Survival, pH Homeostasis, Mitochondrial Functions
Methyl jasmonate (MJ) exhibits antitumor activity against T-cell lymphoma by targeting HIF-1, hexokinase 2, and Hsp70, inducing apoptosis and necrosis through multiple pathways, including altered cell survival and
2021·3citations·Yugal Goel et al.·Frontiers in Pharmacology
Frontiers in Pharmacology