J. E. Powell, S. Kulprathipanja, D. Johnson
Dec 20, 1972
Citations
0
Influential Citations
4
Citations
Journal
Journal of Chromatography A
Abstract
Abstract The techniques of ion exclusion and ion exchange have been exploited to obtain substantial yields of 2,3-dihydroxy-2-methylbutanamide and 2,3-dihydroxy-2-methylbutanoic acid, respectively, following acid hydrolysis of acetoin cyanohydrin. The reaction of acetoin with anhydrous HCN appears to be stereospecific, since the overall process yields an unexpectedly high percentage of only one of two possible diastereomeric dl -acid mixtures, namely, the racemate comprised of (2S,3R)-2,3-dihydroxy-2-methylbutanoic and (2R,3S)-2,3-dihydroxy-2-methylbutanoic acids.