Xu Zhao-yu
2004
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Journal
Chemical Techno-Economics
Abstract
This paper summarized the application,properties of 7-amino-3-desace toxycephalosporanic acid(7-ADCA)and 7-aminocephalosporanic acid(7-ACA). ADCA is a important intermediate which can be used to synthesize a number of antibiotis,such as cefradine,cefadroxil,cefalexin,cefetamet pivoxil,and so on. ACA can be used to synthesize antibiotis,such as ceftraixone,cefpodoxime,cefotaxime,ceftizoxime,and so on. The technical development and advances of 7-ADCA and 7-ACA in recent year are also discussed.At the same time,several view points and suggestions on how to quicken pharmaceutical intermediate development were put forward. ADCA and ACA,as medicine intermediate,are serious lack in China so these products have large market space to develop.