Sirawit Wet-osot, Wong Phakhodee, M. Pattarawarapan
Sep 1, 2017
Citations
0
Influential Citations
19
Citations
Journal
The Journal of organic chemistry
Abstract
5-Substituted-2-ethoxy-1,3,4-oxadiazoles were conveniently prepared through a one-pot sequential N-acylation/dehydrative cyclization between ethyl carbazate and N-acylbenzotriazoles in the presence of Ph3P-I2 as a dehydrating agent. Subsequent treatment with a stoichiometric amount of alkyl halides (X = Cl, Br, I) enables a rapid access to a variety of 3,5-disubstituted 1,3,4-oxadiazol-2(3H)-ones in good to excellent yields.