Sudharshan Madapa, Virender Singh, S. Batra
Sep 11, 2006
Citations
0
Influential Citations
34
Citations
Journal
Tetrahedron
Abstract
Abstract An alternate approach to densely substituted quinolines from the products of S N 2 nucleophilic substitution reaction between the acetyl derivatives of the Baylis–Hillman adducts obtained from 2-nitrobenzaldehydes and the carbonyl group containing carbon nucleophiles is described. Treatment of these compounds with SnCl 2 , triggers a tandem reaction wherein reduction of the nitro group is followed by a remarkably regioselective intramolecular cyclization and subsequent dehydrogenation to afford 4-(substituted vinyl)-quinolines.