E. Ramu, B. Rao
Oct 6, 2009
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Journal
Tetrahedron-asymmetry
Abstract
Abstract A short synthesis of hydroxyethylene dipeptide isostere, a core unit of the HIV-protease inhibitors ritonavir and lopinavir, its C-3 epimer and C 2 symmetric diamino diol is described. The crucial aspects of the synthesis are self-cross metathesis and exploitation of C 2 -symmetric of the metathesis product 8 to obtain the required skeleton.