Paper
Artemisinin compounds sensitize cancer cells to ferroptosis by regulating iron homeostasis
Published May 21, 2019 · Guoqing Chen, F. Benthani, Jiao Wu
Cell Death & Differentiation
Q1 SJR score
327
Citations
6
Influential Citations
Abstract
Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.
In Vitro Study
Highly CitedStudy Snapshot
Artemisinin compounds can sensitize cancer cells to ferroptosis by regulating cellular iron homeostasis, potentially enhancing the effect of future ferroptosis-inducing cancer therapies.
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
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References
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Mitochondria play a crucial role in cysteine-deprivation-induced ferroptosis, which may play a role in tumor suppression.
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Molecular cell
BAP1 links metabolic regulation of ferroptosis to tumor suppression
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FINO2 Initiates Ferroptosis Through GPX4 Inactivation and Iron Oxidation
FINO2 initiates ferroptosis in cancer cells by indirectly inhibiting GPX4 enzyme function and directly oxidizing iron, leading to increased lipid peroxidation.
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Citations
Targeting Ferroptosis in Gastrointestinal Tumors: Interplay of Iron-Dependent Cell Death and Autophagy.
Ferroptosis, a distinct cell death mechanism, offers potential for novel treatments in gastrointestinal cancers, offering new hope for patients affected by these tumors.
2025·0citations·Mohamad Hosein Safari et al.·Molecular and cellular probes
Molecular and cellular probes
Transplant oncology and anti-cancer immunosuppressants
Immunosuppressants with dual anti-tumor and immunosuppressive effects can improve outcomes for transplant patients at high risk of tumor occurrence or recurrence.
2025·0citations·Dejun Kong et al.·Frontiers in Immunology
Frontiers in Immunology
Ferroptosis-related signaling pathways in cancer drug resistance
Targeting ferroptosis-related signaling pathways may provide novel therapeutic approaches for drug-resistant cancers, potentially enhancing therapeutic efficacy.
2025·0citations·Yang Yang et al.·Cancer Drug Resistance
Cancer Drug Resistance
Network pharmacological mechanism and molecular experimental validation of artemisinin in the treatment of lung adenocarcinoma.
Artemisinin effectively inhibits lung cancer cell growth and stemness by targeting key molecules in the IL-6 signaling pathway.
2025·0citations·Zhimin Lu et al.·Toxicology and applied pharmacology
Toxicology and applied pharmacology
The intervention of B. longum metabolites in Fnevs' carcinogenic capacity: A potential double-edged sword.
Bifidobacterium longum metabolites show limited anti-colorectal cancer effect, as they can inhibit growth and migration of Fusobacterium nucleatum-infected CRC cells, but may also promote malignancy due to the presence of both probiotics and toxic substances.
2025·0citations·Jingyu Xu et al.·Experimental cell research
Experimental cell research
Research Progress on Natural Products That Regulate miRNAs in the Treatment of Osteosarcoma
Natural compounds that regulate miRNA expression can reduce osteosarcoma cell chemoresistance and enhance chemotherapy efficacy, offering new potential treatment approaches.
2025·0citations·Lin Wang et al.·Biology
Biology