Aspartame induces cancer stem cell enrichment through p21, NICD and GLI1 in human PANC-1 pancreas adenocarcinoma cells.

doi:10.1016/j.fct.2021.112264

Paper

Aspartame induces cancer stem cell enrichment through p21, NICD and GLI1 in human PANC-1 pancreas adenocarcinoma cells.

Published May 13, 2021 · S. Gezginci-Oktayoglu, M. Ercin, Serap Sancar

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

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Abstract

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In Vitro Study

Study Snapshot

Long-term aspartame exposure increases cancer stem cell population and tumor cell aggressiveness in pancreas adenocarcinoma cells, potentially advancing an existing tumor.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Aspartame induces cancer stem cell enrichment through p21, NICD and GLI1 in human PANC-1 pancreas adenocarcinoma cells.

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References

miR‐375 induces adipogenesis through targeting Erk1 in pancreatic duct cells under the influence of sodium palmitate

Long-term saturated fatty acid overexposure can cause intrapancreatic fat accumulation by inducing duct cell differentiation into adipocytes and contribute to cell compensation, with miR-375 potentially being a new target for treating Type 2 diabetes and NAFPD.

Multiple novel hepatocellular carcinoma signature genes are commonly controlled by the master pluripotency factor OCT4

Novel hepatocellular carcinoma signature genes, TK1, TRIP13, and OCT4, are associated with poor prognosis and may serve as biomarkers for early diagnosis and treatment.

Dynamics of Phenotypic Heterogeneity Associated with EMT and Stemness during Cancer Progression

Dynamic phenotypic changes and cellular plasticity, such as epithelial-mesenchymal transition and cancer stemness, contribute to cancer progression and therapy resistance, offering new avenues for designing therapeutic strategies.

The Multifaceted p21 (Cip1/Waf1/CDKN1A) in Cell Differentiation, Migration and Cancer Therapy

p21 plays a crucial role in cell differentiation, migration, and cancer therapy, with potential as a biomarker and therapeutic target depending on its context, localization, and posttranslational modifications.

Effects of hyperglycemia on the progression of tumor diseases

Hyperglycemia can promote tumor growth, increase apoptosis resistance, and enhance chemoresistance in various cancers.

Citations

Stem Cell Theory of Cancer: Clinical Implications for Cellular Metabolism and Anti-Cancer Metabolomics

Understanding cancer metabolism, whether it's a metabolic, genetic, or stem cell disease, can guide cancer research and therapy development.

Association between Artificial Sweetener-Aspartame Consumption and Colorectal Cancer Risk: Evidence-Based Strategies

Low intake of artificial sweeteners may be associated with a lower risk of colorectal cancer.

Updated systematic assessment of human, animal and mechanistic evidence demonstrates lack of human carcinogenicity with consumption of aspartame.

Aspartame consumption is not carcinogenic in humans, with the inconsistent findings of the Ramazzini Institute studies likely due to flaws in study design and conduct.