Current Aspects of Modes of Action of Dapsone

doi:10.1111/j.1365-4362.1988.tb02401.x

Paper

Current Aspects of Modes of Action of Dapsone

Published Oct 1, 1988 · G. Wozel, J. Barth

International Journal of Dermatology

Q1 SJR score

53

Citations

0

Influential Citations

Full textSemantic Scholar

Abstract

Synthesis of 4,4'-diaminodiphenylsulfone (dapsone, DDS, DADPS [Fig. 1]) by Fromm and Wittmann^ in 1908 was the basic step for the worldwide therapeutic use of this compound in leprosy starting in 1941 (Faget et al.^). in addition, dapsone was introduced into chemoprophylaxis of malaria especially as a potential curative agent against chloroquine-resistent strains of plasmodium infections.'' Furthermore, dapsone can be assumed to be an effective therapeutic agent in cutaneous leishmaniasis.'' Actually, dapsone is used in combination with trimethoprim for therapy of Pneumocystis carinii pneumonia in patients with acquired immunodeficiency syndrome (AIDS).^'^ Since 1950, sulfones have also proved to be effective in the treatment of noninfectious inflammatory diseases of the skin such as dermatitis herpetiformis, pustulosis subcornealis, acropustulosis infantilis, and some other dermatoses like necrotizing angiitis that are mainly characterized by neutrophil amplification or circulating immune complexes or both.'''^^ Most of these dermatoses are thought to be of autoimmune nature or demonstrate a prominent infiltrate of polymorphonuclear leukocytes (PMNs) or both. The observed dapsone-induced inhibition of both PMN-mediated cytotoxicity and mitogen-stimulated lymphocyte transformation has provided valuable clues to our understanding of the action mode of dapsone as well as new insights into the pathogenesis of certain inflammatory disorders. A number of reports has recently been published in which a critical investigation of some of the initial findings is undertaken. Thus, we are now about to obtain a more correct view concerning the subtle effects of dapsone on a variety of cells of the host defense sys-

Study Snapshot

Dapsone's action mode involves inhibition of PMN-mediated cytotoxicity and mitogen-stimulated lymphocyte transformation, providing valuable insights into the pathogenesis of various inflammatory disorders.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Sign up to use Study Snapshot

Consensus is limited without an account. Create an account or sign in to get more searches and use the Study Snapshot.

Create an account

Paper

Current Aspects of Modes of Action of Dapsone

Sign up to use Study Snapshot

References

Biologic properties of LTB4 and paf-acether in vivo in human skin.

Leukotriene B4 and platelet-activating factor both increase vascular permeability in human skin, but local production of anti-inflammatory factors may regulate the inflammatory response.

Dapsone in the Treatment of Cutaneous Leishmaniasis

Dapsone effectively treats cutaneous leishmaniasis, but caution is needed when using it with other medications and avoiding direct contact with colored photographic developers.

Sulfone therapy in the treatment of leukocytoclastic vasculitis. Report of three cases.

Dapsone therapy shows promise in treating common forms of leukocytoclastic vasculitis, with prompt disappearance of new lesions and rapid recurrence after discontinuing therapy.

Selective inhibition of human neutrophil chemotaxis to N-formyl-methionyl-leucyl-phenylalanine by sulfones.

Sulfones selectively inhibit neutrophil migration to F-met-leu-phe, suggesting their potential role in treating neutrophilic dermatoses by targeting undefined chemoattractants in the skin.

Dapsone-trimethoprim for Pneumocystis carinii pneumonia in the acquired immunodeficiency syndrome.

Dapsone-trimethoprim is an effective and well-tolerated treatment for Pneumocystis carinii pneumonia in patients with acquired immunodeficiency syndrome, with a lower frequency of serious side effects compared to trimethoprim-sulfamethox

Citations

Impurity profiling of dapsone using gradient HPLC method.

A new gradient HPLC method for dapsone impurity profiling provides improved selectivity and sensitivity, enabling a 0.02% limit of detection for all specified impurities.

Dapsone Attenuates the Severity of Gastric Erosion Induced by Ethanol; Stress; and Indomethacin in Rats: A Pharmacological Approach

Dapsone exhibits significant gastro-protective effects against the development of experimental gastric erosions in rats, likely due to its anti-inflammatory properties.

Review of the syntheses and activities of some sulfur-containing drugs.

Sulfur-containing compounds show potential in treating various diseases and offer potential for new drug candidates.

Amino Acid Variants of HLA-DRB1 Confer Susceptibility to Dapsone Hypersensitivity Syndrome in Addition to HLA-B*13:01.

Five amino acid variants within HLA-DRB1 are significantly associated with dapsone hypersensitivity syndrome in a Chinese population, beyond HLA-B*13:01.

Anti-glioma Activity of Dapsone and Its Enhancement by Synthetic Chemical Modification

Dapsone shows potential anti-glioma activity, which can be further enhanced by molecular modifications, making it a potential therapeutic adjunct for glioma treatment.

Comparative Study of Efficacy of Topical Dapsone 5% Gel, Topical Benzoyl Peroxide 2.5% Alone and in Combination in Acne Vulgaris Patients

Topical dapsone 5% gel and benzoyl peroxide 2.5% alone show better results in treating acne vulgaris than when used together.

Designing dapsone polymer conjugates for controlled drug delivery.

Dapsone-conjugated methacrylic monomer and polymer derivatives show potential for developing advanced anti-inflammatory therapies, potentially benefiting rare autoimmune and inflammatory diseases.