We report 5 cases of invasive aspergillosis occurring in severely immunosuppressed patients hospitalized with pandemic influenza A (H1N1). We suggest that infection with influenza A (H1N1) may predispose immunocompromised patients to develop invasive aspergillosis. Physicians should be aware of this potential association to allow early diagnosis and prompt treatment of aspergillosis.

Invasive aspergillosis may occur in severely immunocompromised patients hospitalized with pandemic influenza A (H1N1), highlighting the need for early diagnosis and prompt treatment.

Invasive aspergillosis complicating pandemic influenza A (H1N1) infection in severely immunocompromised patients.

Key Takeaway: Invasive aspergillosis may occur in severely immunocompromised patients hospitalized with pandemic influenza A (H1N1), highlighting the need for early diagnosis and prompt treatment.