Azines and Azoloazines, Part 1: Reactions of Triazolo[3,4‐a]phthalazine and Its Derivatives with Carbanions

doi:10.1002/JHET.1019

Paper

Azines and Azoloazines, Part 1: Reactions of Triazolo[3,4‐a]phthalazine and Its Derivatives with Carbanions

Published Nov 1, 2014 · Wiktoria Zinczenko, Marek K. Bernard, I. Okulicz-Kozaryn

Journal of Heterocyclic Chemistry

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Abstract

Triazolo[3,4-a]phthalazine as well as their chloro and nitro derivatives were subjected to the reactions with the carbanions typical for the vicarious nucleophilic substitution (VNS) of hydrogen. The reactions were strongly dependent on the substituents present on the triazolo[3,4-a]phthalazine ring and resulted not only in the substitution of hydrogen but also in exchange of chlorine atom and pyridazine ring scission; the latter process dominated for the unsubstituted triazolophthalazine. Two of the products showed promising stimulating activity towards the central nervous system with no significant toxic effects.

Study Snapshot

Triazolo[3,4-a]phthalazine and its derivatives show promising central nervous system stimulating activity without significant toxic effects when reacting with carbanions.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Azines and Azoloazines, Part 1: Reactions of Triazolo[3,4‐a]phthalazine and Its Derivatives with Carbanions

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Citations

Introduction of Carbon Substituents into Nitroarenes via Nucleophilic Substitution of Hydrogen: New Developments

Nucleophilic substitution of hydrogen in nitroarenes allows for the introduction of alkyl and functionalized alkyl substituents, leading to the construction of carbo- and heterocyclic rings and the investigation of the mechanism of SNArH.