A. Abdel-Magid
Nov 8, 2012
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Journal
ACS medicinal chemistry letters
Abstract
The invention in this patent application relates to novel 8-amino-5,6-dihydroimidazo[1,2- a ]pyrazine derivatives represented by Formula (I), which inhibit the enzyme β -secretase, also known as β -site amyloid cleaving enzyme (BACE). The β -secretase (BACE) and γ -secretase enzymes cleave the amyloid precursor protein (APP) sequentially at the N and C termini to generate β -amyloid 1 − 42 [Abeta (or A β ) 1 − 42] as well as A β 1 − 38 and A β 1 − 43 peptides. These peptides can aggregate to form oligomers, fi brils, and eventually amyloid plaques. The accumulation of amyloid plaques in the brain is a major characteristic pathological