Structural Basis for Carbapenem-Hydrolyzing Mechanisms of Carbapenemases Conferring Antibiotic Resistance

doi:10.3390/ijms16059654

Paper

Structural Basis for Carbapenem-Hydrolyzing Mechanisms of Carbapenemases Conferring Antibiotic Resistance

Published Apr 29, 2015 · J. Jeon, Jung Hun Lee, Jae Jin Lee

International Journal of Molecular Sciences

Q1 SJR score

160

Citations

5

Influential Citations

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Abstract

Carbapenems (imipenem, meropenem, biapenem, ertapenem, and doripenem) are β-lactam antimicrobial agents. Because carbapenems have the broadest spectra among all β-lactams and are primarily used to treat infections by multi-resistant Gram-negative bacteria, the emergence and spread of carbapenemases became a major public health concern. Carbapenemases are the most versatile family of β-lactamases that are able to hydrolyze carbapenems and many other β-lactams. According to the dependency of divalent cations for enzyme activation, carbapenemases can be divided into metallo-carbapenemases (zinc-dependent class B) and non-metallo-carbapenemases (zinc-independent classes A, C, and D). Many studies have provided various carbapenemase structures. Here we present a comprehensive and systematic review of three-dimensional structures of carbapenemase-carbapenem complexes as well as those of carbapenemases. We update recent studies in understanding the enzymatic mechanism of each class of carbapenemase, and summarize structural insights about regions and residues that are important in acquiring the carbapenemase activity.

Systematic Review

Highly Cited

Study Snapshot

This study reviews the 3D structures of carbapenemase-carbapenem complexes, providing insights into the enzymatic mechanisms and key regions for carbapenemase activity in antibiotic-resistant bacteria.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Structural Basis for Carbapenem-Hydrolyzing Mechanisms of Carbapenemases Conferring Antibiotic Resistance

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References

Citations

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Acinetobacter baumannii poses a significant global healthcare challenge due to its multidrug resistance and ability to cause various infections, necessitating a comprehensive understanding of its resistance acquisition and pathogenicity for effective combating.

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Carbapenem-resistant Escherichia coli and Klebsiella pneumoniae are resistant to multiple antibiotics but still susceptible to tigecycline, fosfomycin, and amikacin.

Genotypic Characterisation of Carbapenem-Resistant Enterobacteriaceae in a Tertiary Care Hospital in South India

Carbapenem-resistant Enterobacteriaceae are prevalent in South India, with metallo--lactamase being the primary source of resistance.

Genetic characteristics and diversity of PDC variants of Pseudomonas aeruginosa and its clinical relevance.

PDC-447 is the most widespread PDC variant in Indian P. aeruginosa, contributing to antibiotic resistance, and understanding their genetic characteristics is crucial for developing effective treatment strategies.

Overview of β-Lactam-Resistance Genes in Pandemic Multidrug-Resistant Acinetobacter baumannii: A Troublesome Pathogen in the Indian Intensive Care Unit

ADC2 and OXA23 genes are highly prevalent in pandemic Acinetobacter baumannii, leading to increased resistance to -lactam antibiotics in Indian ICUs.

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Recent advances in antibiotic resistance mechanisms and emerging treatments, such as artificial intelligence and biological therapy, show promise in combating drug-resistant P. aeruginosa.

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