Brater Dc
Feb 1, 1996
Citations
0
Influential Citations
27
Citations
Journal
Drug Safety
Abstract
Torasemide is a lipophilic anilinopyridine sulphonylurea derivative that acts as a high ceiling loop diuretic and has been used for the treatment of both acute and chronic congestive heart failure (CHF) and hypertension. Torasemide is similar to other loop diuretics in terms of its mechanism of diuretic action; namely, blockade of Na+/K+/2Cl− cotransport in the thick ascending limb of the loop of Henle. It has high bioavailability (>80%), as does bumetanide, but a longer elimination half-life (3 to 4 hours) than either bumetanide or furosemide (frusemide).