Benzo[b]-1,8-naphthyridine derivatives: synthesis and reversal activity on multidrug resistance.

Paper

Benzo[b]-1,8-naphthyridine derivatives: synthesis and reversal activity on multidrug resistance.

Published Aug 19, 2002 · H. Misbahi, P. Brouant, A. Hevér

Anticancer research

Q2 SJR score

18

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0

Influential Citations

Semantic Scholar

Abstract

A series of benzo[b]-1,8-naphthyridine derivatives branched with various side-chains and substituents were prepared with the aim of being investigated as multidrug resistance (MDR) modulators. The syntheses were achieved from 2-halonicotinic acid and suitable aryl-amines according to a three-step procedure. All the derivatives were tested in vitro on mouse T-Lymphoma cell line L5178 transfected by MDR1 gene and the chemosensitizing properties of the compounds were compared to those of verapamil and propranolol, as well as to several other tricyclic derivatives like phenothiazines and acridines. Most of the compounds tested reversed the MDR of tumour cells more effectively than the reference drugs did and they showed more potent chemosensitizing activity than phenothiazine and acridine derivatives have.

In Vitro Study

Study Snapshot

Benzo[b]-1,8-naphthyridine derivatives show potential as effective multidrug resistance modulators, with more potent chemosensitizing activity than phenothiazine and acridine derivatives.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Benzo[b]-1,8-naphthyridine derivatives: synthesis and reversal activity on multidrug resistance.

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