A benzodiazepine recognition site associated with the non-NMDA glutamate receptor

doi:10.1016/0896-6273(93)90242-J

Paper

DOI: 10.1016/0896-6273(93)90242-J

A benzodiazepine recognition site associated with the non-NMDA glutamate receptor

Published Jan 31, 1993 · C. Zorumski, Kelvin A. Yamada, M. Price

Neuron

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198

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Abstract

Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.

Highly Cited

Study Snapshot

GYKI 52466 acts noncompetitively to block ion currents and excitotoxicity mediated through non-NMDA glutamate receptors, offering a promising new target for treating neurological disorders.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Citations

DOI: 10.1101/2023.11.28.569057

Allosteric Competition and Inhibition in AMPA Receptors

Non-competitive inhibition of AMPARs by negative allosteric modulators like GYKI-52466 effectively desensitizes them to activation and prevents positive allosteric modulation, potentially benefiting therapeutic design in neurological diseases.

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NMDAR-dependent presynaptic homeostasis in adult hippocampus: Synapse growth and cross-modal inhibitory plasticity

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Synaptic plasticity in the auditory system: a review

Short-term depression is significantly less in auditory synapses than in non-auditory ones, enabling reliable, failure-free synaptic transmission at frequencies >100 Hz.

2015·39citations·E. Friauf et al.·Cell and Tissue Research

Cell and Tissue Research

DOI: 10.1016/j.neuroscience.2012.11.063

Low-dose GYKI-52466: Prophylactic preconditioning confers long-term neuroprotection and functional recovery following hypoxic–ischaemic brain injury

Low-dose GYKI-52466 preconditioning effectively reduces infarct volume and ventricular enlargement in a rat model of hypoxic-ischaemic brain injury, offering a novel neuroprotective strategy.

2013·5citations·P. Nayak et al.·Neuroscience

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DOI: 10.1016/j.neuroscience.2012.12.001

Determination of 1-(4′-aminophenyl)-4-methyl-7,8-methylene-dioxy-2,3-benzodiazepine by high-performance liquid chromatography–diode array detection in plasma and brain in healthy and hypoxic–ischaemic rats

GYKI-52466, a metabotropic neuroprotective agent, shows low-dose neuroprotective efficacy in healthy and brain-damaged rats, with no evidence of a'surge' in brain concentrations at the injury site.

2013·3citations·P. K. Nayak et al.·Neuroscience

Neuroscience