Benzydamine reduces prostaglandin production in human gingival fibroblasts challenged with interleukin-1 beta or tumor necrosis factor alpha.

Paper

Benzydamine reduces prostaglandin production in human gingival fibroblasts challenged with interleukin-1 beta or tumor necrosis factor alpha.

Published 1999 · T. Modéer, T. Yucel-Lindberg

Acta odontologica Scandinavica

Q2 SJR score

5

Citations

0

Influential Citations

Semantic Scholar

Abstract

Benzydamine [1-benzyl-3-(3-dimethylamino)propoxy-1H-indazole] is a drug with analgesic, anesthetic, antimicrobial and anti-inflammatory activity. The purpose of the present study was to investigate the effect of benzydamine on prostaglandin production in human gingival fibroblasts. Benzydamine significantly reduced the basal production of both prostaglandin E2 (PGE2) and 6-keto-PGF1 alpha, the stable breakdown product of prostaglandin I2 (PGI2), in unstimulated human gingival fibroblasts. When the cells were treated simultaneously with benzydamine and the cytokines IL-1 beta or TNF alpha, the agent benzydamine reduced (P < 0.05) the stimulatory effect of IL-1 beta and TNF alpha respectively, on PGE2 and PGI2 production in human gingival fibroblasts. Furthermore, benzydamine reduced (P < 0.05) both the basal level and the cytokine-induced 3H-arachidonic acid release 3H-(AA) in gingival fibroblasts. The addition of exogenous arachidonic acid to the cells resulted in enhanced PGE2 production, which was reduced (P < 0.05) in the presence of benzydamine. The study indicates that benzydamine reduces the prostaglandin synthesis in gingival fibroblasts, partly at the level of phospholipase A2, by diminishing the liberation of arachidonic acid (AA) from phospholipids, and partly at the level of cyclooxygenase. The inhibitory effect of benzydamine on prostaglandin production may explain the anti-inflammatory effect of the drug in the management of patients with oral inflammatory conditions.

In Vitro Study

Study Snapshot

Benzydamine reduces prostaglandin production in human gingival fibroblasts, potentially explaining its anti-inflammatory effect in oral inflammatory conditions.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Benzydamine reduces prostaglandin production in human gingival fibroblasts challenged with interleukin-1 beta or tumor necrosis factor alpha.

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References

Citations

Efficacy of ketamine gargle 40 mg and benzydamine HCl 0.075% in reducing post intubation sore throat

Ketamine gargle 40 mg 5 minutes before intubation is more efficient in reducing post-intubation sore throat compared to benzydamine HCl 0.075% at fully awake and 2 hours post-extubation.

Effect on Postoperative Sore Throat of Spraying the Endotracheal Tube Cuff with Benzydamine Hydrochloride, 10% Lidocaine, and 2% Lidocaine

Spraying benzydamine hydrochloride on the endotracheal tube cuff effectively reduces the incidence and severity of postoperative sore throat.

A COMPARATIVE STUDY ON BENZYDAMINE HCL 0.5% AND ACETAMINOPHEN CODEINE IN PAIN REDUCTION FOLLOWING PERIODONTAL SURGERY

Acetaminophene codeine is more effective than benzydamine HCL in reducing post-operative pain after periodontal surgery, but both can be used to reduce systemic drug consumption.

Benzydamine: an alternative nonsteroidal anti‐inflammatory drug in patients with nimesulide‐induced urticaria

Benzydamine is a tolerable alternative NSAID for patients with nimesulide-induced urticaria, providing an alternative treatment option.