Robert L. Dow, B. Bechle, Thomas T. Chou
May 1, 1991
Citations
0
Influential Citations
60
Citations
Journal
Journal of medicinal chemistry
Abstract
A series of benzyloxazolidine-2,4-diones, containing oxazole-based side chains, were found to lower blood glucose levels in the genetically obese ob/ob mouse. Incorporation of a benzofuran structural element in these compounds provides greatly enhanced in vivo potency. The syntheses and structure-activity relationships for this series are detailed.