New Biguanides as Anti-Diabetic Agents Part I: Synthesis and Evaluation of 1-Substituted Biguanide Derivatives as Anti-Diabetic Agents of Type II Diabetes Insulin Resistant

doi:10.1055/s-0043-102692

Paper

New Biguanides as Anti-Diabetic Agents Part I: Synthesis and Evaluation of 1-Substituted Biguanide Derivatives as Anti-Diabetic Agents of Type II Diabetes Insulin Resistant

Published Jun 26, 2017 · S. Abbas, W. Basyouni, K. El-Bayouk

Drug Research

Q3 SJR score

10

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0

Influential Citations

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Abstract

Abstract New 1-substituted-biguanide hydrochloride salts were synthesized via reacting benzo[1,3-d]dioxol-5-amine, phenylhydrazine, N,N-dimethylhydrazinecarboxamide, benzohydrazide and 2-phenyl acetohydrazide with dicyandiamide in acidic medium. Structures of the obtained biguanide salts were characterized by spectroscopic tools. The synthesized compounds were screened for their anti-diabetic activity with standard metformin drug. Oral treatment of hyperglycemic rats with the synthesized biguanide derivatives significantly decreased the elevated blood glucose level. Additionally, anti-diabetic properties towards liver function enzyme activities (AST, ALT and ALP), lipids profiles (TC, TG and TL), lipid peroxide and nitrous oxide as well as histopathological studies relative to metformin hydrochloride were investigated and discussed.

Non-RCT

Animal Study

Study Snapshot

New 1-substituted biguanide derivatives show significant anti-diabetic activity in rats, with potential for use in type II diabetes insulin-resistant patients.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

New Biguanides as Anti-Diabetic Agents Part I: Synthesis and Evaluation of 1-Substituted Biguanide Derivatives as Anti-Diabetic Agents of Type II Diabetes Insulin Resistant

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References

Citations

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Indolizine derivatives show promising antidiabetic activity, with C8 showing significant reduction of streptozotocin-induced blood glucose in rats compared to metformin.

Design, synthesis and chemical stability of indolizine derivatives for antidiabetic activity

Indolizine derivatives show promising antidiabetic activity, with C8 showing significant reduction of STZ-induced blood glucose in rats compared to metformin.

Biguanides: Species with versatile therapeutic applications.

Biguanides exhibit diverse therapeutic properties, including antimalarial, antidiabetic, antiviral, anticancer, and other biological activities, making them a promising class of compounds for medicinal chemistry research.

Coordination Compounds of Platinum and Palladium with Mixed Ligands (Usnic Acid and 1-(o-Tolyl) Biguanide) � Synthesis, Spectral Characterization and Biological Activity

The synthesized coordination compounds of Pd(II), Pt(II) and Pt(IV) with usnic acid and 1-(o-tolyl)biguanide show potential as antimicrobial, antifungal, and antitumor agents.