Biologic action of betamethasone 17,21-dipropionate in rat and dog.

doi:10.1016/0039-128X(72)90014-1

Paper

DOI: 10.1016/0039-128X(72)90014-1

Biologic action of betamethasone 17,21-dipropionate in rat and dog.

Published Nov 1, 1972 · E. Collins, J. Aschenbrenner, M. Nakahama

Steroids

Q2 SJR score

Citations

Influential Citations

Full textSemantic Scholar

Abstract

Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.

Non-RCT

Animal Study

Study Snapshot

Betamethasone 17,21-dipropionate is a potent and effective anti-inflammatory agent for dogs, with slow release from the injection site without loss of efficacy.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Sign up to use Study Snapshot

Consensus is limited without an account. Create an account or sign in to get more searches and use the Study Snapshot.

Create an account

Full text analysis coming soon...

References

DOI: 10.1016/0039-128X(67)90037-2

17-Esters and 17, 21-diesters of 9α, 11β-dichlorocorticoids. Synthesis and anti-inflammatory activity

17-Esters and 17, 21-diesters of 9, 11-dichlorocorticoids show anti-inflammatory activity, with maximum activity in 17-butyrate and 17-valerate of 16-methyldichlorisone.

1967·9citations·E. Shapiro et al.·Steroids

Steroids

DOI: 10.1111/j.1749-6632.1960.tb44964.x

LABORATORY EVALUATION OF ANTI‐INFLAMMATORY STEROIDS

The eosinophil assay is a reliable measure of corticoid activity, with excellent correlation to therapeutic activity, while classic methods like liverglycogen and thymus involution may have limited predictive value.

1959·37citations·S. Tolksdorf·Annals of the New York Academy of Sciences

Annals of the New York Academy of Sciences

DOI: 10.1002/JPS.3030460902

Effect of alterations in side chain upon anti-inflammatory and liver glycogen activities of hydrocortisone esters.

Hydrocortisone esters' anti-inflammatory and liver glycogen activities vary depending on their side chain configuration, with tertiary butyl acetate being particularly effective when applied locally and 9-fluoro derivative providing a more sustained response.

1957·304citations·C. Winter et al.·Journal of the American Pharmaceutical Association. American Pharmaceutical Association

Journal of the American Pharmaceutical Association. American Pharmaceutical Association

DOI: 10.1210/ENDO-48-3-316

A method of assaying adrenal cortical hormones based on a decrease in the circulating eosinophil cells of adrenalectomized mice.

This study proposes a quick bioassay procedure for adrenal cortical hormones based on a decrease in circulating eosinophil cells in adrenalectomized mice, which may provide a satisfactory method for rapid detection of these hormones.

1951·38citations·R. Speirs et al.·Endocrinology

Endocrinology

Citations

DOI: 10.1002/0471266949.BMC192

Anti‐Inflammatory Glucocorticoids

Selective receptor modulators can maintain beneficial therapeutic activity with a diminished risk of side effects in treating inflammatory conditions.

2010·2citations·M. Avery et al.·Burger's Medicinal Chemistry and Drug Discovery

Burger's Medicinal Chemistry and Drug Discovery

DOI: 10.1126/SCIENCE.6296999

Anti-inflammatory steroids without pituitary-adrenal suppression.

Methyl prednisolonate and methyl 20-dihydroprednisolonate show anti-inflammatory properties similar to prednisolone when applied locally, but weaker systemically, and do not suppress pituitary-adrenal function or cause liver glycogen de

1982·90citations·H. J. Leè et al.·Science

Science

DOI: 10.1016/0024-3205(80)90234-9

Corticosteroidogenesis in the hypertrophic adrenal gland produced by betamethasone 17,21-dipropionate in the rat fetus.

No qualitative alterations in corticosteroidogenesis occurred in hypertrophic adrenal glands caused by BMDP in the rat fetus, but corticosterone levels were higher than normal.

1980·2citations·Y. Hasegawa et al.·Life sciences

Life sciences

DOI: 10.1016/0006-2952(79)90352-6

Suppression of glycogen storage with betamethasone 17,21-dipropionate in fetal rat liver--II. Inhibition of glycogenic action of cortisol and insulin in the liver in organ culture.

Betamethasone 17,21-dipropionate effectively suppresses the glycogenic actions of cortisol and partially suppresses insulin-induced glycogen accumulation in fetal rat liver in organ culture.

1979·11citations·Y. Mizushima·Biochemical pharmacology

Biochemical pharmacology

DOI: 10.1016/0006-2952(79)90351-4

Suppression of glycogen storage with betamethasone 17,21-dipropionate in fetal rat liver--I. Effect on metabolites of the glucogenic pathway and glycogen synthase activity.

Betamethasone 17,21-dipropionate suppresses glycogen accumulation in fetal rat liver during late pregnancy, with inhibition between UDP-glucose and glycogen playing a key role in this action.

1979·5citations·Y. Mizushima et al.·Biochemical pharmacology

Biochemical pharmacology