Biologic activity of 6-alph-amethyl compounds corresponding to progesterone, 17-alpha-hydroxyprogesterone acetate and compound S.

Paper

Biologic activity of 6-alph-amethyl compounds corresponding to progesterone, 17-alpha-hydroxyprogesterone acetate and compound S.

Published May 1, 1959 · Glenn Em, Richardson Sl, B. Bowman

Metabolism: clinical and experimental

Q1 SJR score

59

Citations

1

Influential Citations

Semantic Scholar

Abstract

The results of an investigation of related 6-alpha-methyl steroids and their effect on certain specific biologic end points are presented. The 6-alpha-methyl steroids otherwise corresponding to progesterone 17-alpha-hydroxyprogesterone 17-alpha-hydroxyprogesterone acetate and compound S had significant antiinflammatory glycogenic and pituitary-inhibiting activity in the rate. This combination of biologic properties has heretofore been ascribed only to steroids which possess both the 11-beta and C-21 hydroxyl groups. When administered systemically at reasonable dose levels the corresponding steroids without the 6-alpha-methyl group did not demonstrate a similar degree of antiinflammatory or pituitary-inhibiting activity and glycogenic activity could not be detected. When injected directly into the croton oil-induced granuloma pouch however both the nonmethylated and to a greater degree the 6-alpha-methylated steroids showed significant antiinflammatory activity. Comparisons of the metabolism or inactivation of 6-alpha-methyl-17-alpha-hydroxyprogesterone acetate (6-MAP) and of progesterone by partially purified rat liver enzyme systems indicated that progesterone is metabolized more rapidly. Failure to demonstrate systemic antiinflammatory or glycogenic activity with progesterone or compound S may therefore result from their rapid inactivation by the liver. 6-MAP was markedly active in inhibiting both adrenal and gonadal function in male and female weanling rats. It was more potent in producing adrenal suppression than hydrocortisone and achieved this effect at doses which did not inhibit growth whereas hydrocortisone did. In contrast to hydrocortisone its adrenal-inhibiting effects persisted for at least 2 weeks after hormone treatment was discontinued. These effects were apparently mediated throught the anterior pituitsry. It is concluded that these studies have the following important theoretical implications: 1) the concept that certain structural features on the steroid molecule are absolutely necessary for specific biologic effects does not hold up and 2) it may well be that "stripped down" adrenocortical steroids will be found that have biologic activities now attributed only to more complete molecular structures.(Authors modified)

Non-RCT

Animal Study

Study Snapshot

6-alpha-methyl steroids, such as progesterone and 17-alpha-hydroxyprogesterone acetate, show significant antiinflammatory, pituitary-inhibiting, and glycogenic properties, suggesting that structural features on steroids are not essential for specific biologic effects.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Biologic activity of 6-alph-amethyl compounds corresponding to progesterone, 17-alpha-hydroxyprogesterone acetate and compound S.

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References

Citations

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