Manvinder Kaur, M. Yusuf, D. S. Malhi
Jul 13, 2020
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Journal
Current organic synthesis
Abstract
AIM AND OBJECTIVE Isoxazole is an active core found in many drugs. The aim of this work was to synthesize bis-isoxazoline compounds and to analyze the effect of linker chain length on the biological activities. MATERIAL AND METHODS A simple, convenient and efficient method for the conversion of bischalcones to new bis(4,5- dihydroisoxazole) derivatives was developed by using hydroxylamine hydrochloride under basic medium. Synthesized moieties were also evaluated for their antimicrobial potencies and DNA photocleavage assay. RESULTS The synthesized compounds are more active than their chalcone precursors and the long-chain linkers (4e&4f) were more potent in anti-microbial as well as in DNA photocleavage activity. CONCLUSION It was found that many of the tested bischalcones and bis-isoxazolines exhibited moderate to significant antimicrobial activity against various strains. Furthermore, the present study also provides significant information and interesting outcomes regarding cyclization, increasing length of linker chains and their effects on the DNA photocleavage and antimicrobial activities.