R. Worz, Barbara Reinhardt-Benmalek, K. Grotemeyer
Jun 1, 1991
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0
Influential Citations
22
Citations
Quality indicators
Journal
Cephalalgia
Abstract
Introduction Bisoprolol (1) is a long-acting highly beta, -selective adrenoceptor antagonist, used for the treatment of hypertension and angina pectoris (therapeutic dose range: between 5 mg and 10 mg once daily). In common with other beta-blockers shown to be effective in migraine prevention, bisoprolol is pharmacologically characterized by absent intrinsic sympathomimetic activity (ISA). The objective of this study was to compare the efficacy and safety of bisoprolol (510 mg once daily) in migraine prophylaxis with that of the beta, -selective blocker metoprolol (50-100 mg twice daily), a well established migraine prophylactic drug.