Taeyoung Choi, E. Ma
Jan 29, 2007
Citations
0
Influential Citations
7
Citations
Journal
Molecules
Abstract
Bromination of 5,6-dimethoxyindan-1-one with Br(2) in acetic acid at room temperature produced exclusively the corresponding 2,4-dibromo compound in 95% yield. Reaction of 5,6-dimethoxyindan-1-one with Br(2) in the presence of KOH, K(2)CO(3) or Cs(2)CO(3 )at ~0 degrees C( )gave the monobrominated product 4-bromo-5,6-dimethoxyindan-3-one in 79%, 81% and 67% yield, respectively. 5,6-Dihydroxyindan-1-one was dibrominated on the aromatic ring affording 4,7-dibromo-5,6-dihydroxyindan-1-one both in acetic acid at room temperature and in the presence of KOH at ~0 degrees C. 5,6-Difluoroindan-1-one and 1-indanone were alpha-monobrominated in acetic acid and alpha,alpha-dibrominated under KOH conditions at room temperature.